Recent Publication in Human Molecular Genetics

The transient receptor potential vanilloid 1 (TRPV1) protein is a pain receptor that elicits a hot sensation when an organism eats the capsaicin of red chili peppers. Sustained intracellular Ca2+ signaling disruption may have an early and significant role in Alzheimer's disease (AD) pathogenesis. We discovered that knocking-out Ca2+-permeable TRPV1 pain receptors rescued memory deficits and the production of Aβ, tau, and p-tau. The TRPV1 antagonist, which can modulate disrupted Ca2+ homeostasis in AD-affected neurons, might have therapeutic potential for the treatment of AD.

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Grant (중견)

"뇌건강 foodome-physiome-exposome 지식을 기반으로 하는 개인 맞춤 브레인 푸드 머신러닝 예측 모델 개발" 연구가 한국연구재단 중견연구사업에 선정되었습니다. (2021.03.01 - 2023.02.28) (주)디이프와 공동으로 연구합니다.