The transient receptor potential vanilloid 1 (TRPV1) protein is a pain receptor that elicits a hot sensation when an organism eats the capsaicin of red chili peppers. Sustained intracellular Ca2+ signaling disruption may have an early and significant role in Alzheimer's disease (AD) pathogenesis. We discovered that knocking-out Ca2+-permeable TRPV1 pain receptors rescued memory deficits and the production of Aβ, tau, and p-tau. The TRPV1 antagonist, which can modulate disrupted Ca2+ homeostasis in AD-affected neurons, might have therapeutic potential for the treatment of AD.
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